quick and dirty answer,
if you are feeding a monoband di pole use coax,
if feeding a multiband, cut it for the lowest band, feed it with ladderline and use a tuner on the higher bands
The primary advantages of coax with respect to ladder line are
- most transceivers are equipped with coax connectors, whereas using ladder line requires a balun or balanced tuner
- coax is not affected by nearby metal objects, unlike ladder line
- the impedance of coax doesn't change when it rains or snows, unlike ladder line
The primary advantages of ladder line with respect to coax are
- lower loss at frequencies of 28 MHz and up
- easier to make connections
- can drive a balanced antenna (e.g. a dipole) without a balun
- lower weight