I run Digital Trends LMR400 on my base, original old antron (side mounted antron), no issues whatsoever.
A friend of mine runs Digital Trends LMR400 on his base maco v5000 running around 2kw at all times, no issues whatsoever. He achieved a 2db increase in receive and transmit after changing over from RG213 to tuned (nulled) lengths on his jumpers and coax of LMR400.
Our local amp tech switched over from RG213 to tuned (nulled) lengths of Times Microwave LMR400 on his maco v5000 running around 2kw at all times, no issues whatsoever.
Another local friend of mine switched over from RG8U to tuned (nulled) lengths of Times Microwave LMR400 on his solarcon and all his jumpers, running between 250w up to 2kw, never had an issue.
We all noticed big differences in our receive and transmit after switching over, and haven't looked back.
It's all in the VF (Velocity Factor), after applying the null calculation.
RG213 VF - .66, meaning only 66% of your power is actually making it to the antenna after cutting for that VF.
RG8U VF - .74, meaning only 74% of your power is actually making it to the antenna after cutting for the VF.
RG8X VF - .82............
LMR400 VF - .84........
You get the picture.