the 1st vehicle i ever worked on that totally crapped out by use of an amplifier on cb was an early 2000's gmc general truck tractor. an unmodded export am/fm with a dx500 (or maybe 667, don't remember), and a well mounted single mirror mount, wilson 2000 i think, would cause the truck to buck & miss while at idle. moving things around in the cab didn't help. pretty much anything more then 100w pep caused trouble. while on the highway, the truck died. the computer was diagnosed as to having been affected by excessive rf. how the gmc dealer came up with this, i can't really say, but the computer required replacement as it could not be reprogrammed. my customer was required to use only company authorized radios. my customer is now an xm satellite user & even 10 years later does not have a cb in his company truck.
i believe back in the 90's, a particular toyota model car had issues with even 100 watt radios.
the newest vehicle that i have worked on with any reasonable power was a non-hemi 2007 dodge truck. 800 watts from a dx1200 driven by an ic706mk2g measured by a coaxial dynamics pep meter into any of several different antennas mounted on the top of the side bedrail worked ALMOST flawlessly. there were some issues with dash lights flashing, wipers wiping, and the stereo not working properly-depending on which antenna was used. an 8' whip caused the most problems, a 5' skipshooter the least, and a predator 10k & wilson 5k (i think) were mostly ok.
a 2003 hummer h2, 5x16 messenger with a magnet mount predator worked flawlessly, a 2001 dodge truck would not run right at all with a davemade 4 pill and a mag mount, yet after drilling some holes the 4 was upgraded to a 2x8 fatboy & ran just fine.
on NONE of these trucks did i do any ferrite beads, wrap the computer in aluminum foil, add 500' of ground straps. an unmodified radio is the best starting point.